Collagenase is an enzyme that has the ability to digest collagen. It is injected into the scar tissue (usually referred to as: plaque ) that causes Peyronies Disease.
Can it straighten a bent penis caused by Peyronies disease?
No. Not really. Well, up to 35%. But, that is only for certain types of cases.
The only FDA approved form of collagenase for straightening a bent penis caused by Peyronies Disease is called XIAFLEX®.
The purpose is to digest the collagen in the scar tissue in hopes of softening the scar(s) and relieving the condition.
It is one of the multitude of chemical substances, including: dimethyl sulfoxide, calcium channel blockers, colchicine, interferon, and steroids, that medical doctors use in an attempt to soften the scar tissue in Peyronies Disease.
The hope is that the scar tissue will then become soft and supple enough so that the tissue can stretch properly and evenly during erection.
It has proven to be the most promising of all these chemicals. Still, the results from it have only been marginal.
The most recent development of this enzyme for treating Peyronies disease is called Xiaflex.
It has shown the best results of all the enzyme injections available. It's cost? About $30,000 for a full set of treatments.
Considering that a bent penis can be straightened 99.99% of the time with just correct Penis Traction Therapy, for a cost of under $300, yes under three hundred dollars, is XIAFLEX® really worth the price?
collagenase solution is injected
directly into each fibrous Peyronies plaque (scar).
The collagenase solution is injected directly into each fibrous Peyronies plaque (scar). The injections are made directly into the plaque of a flaccid penis. They are done at the point of maximum concavity with an artificial erection. A small amount of topical anaesthetic such as lidocaine, may be used.
If the scar is straight, it is injected as the needle is withdrawn. If it is a lump or irregular, the needle is fanned within it to distribute the solution within the entire mass.
When the injection is finished, the penile shaft is immobilized. Usually with a bulky gauze dressing and/or an athletic supporter. This prevents it from moving and keeps the collagenase from being flushed out too quickly by the blood flow.
The immobilization lasts for 4 to 12 hours. Usually if the procedure was in the early afternoon, the dressing is removed at bedtime.
Three series of injections are usually done over a week to ten day period. Then repeated again in 6 to 12 week intervals two more times.
These are the results from numerous clinical studies:
1. M. K. Gelbard, et al. Urology Research (1982) 10: 135-1401.
2. Gelbard, M.K., Walsh, R., Kaufman, J.J. Collagenase for Peyronie's Disease Experimental Studies. Urol. Res. (1982) 10:135-140
3. Gelbard, M.K., Lindner, A., Kaufman, J.J. The Use of Collagenase in the Treatment of Peyronie's Disease. J. of Urology: 134, August 1985, 280-283
3. Hamilton, R.G., Mintz, G.R., Gelbard, M.K. Humoral Immune Responses in Peyronie's Disease Patients Receiving Clostridial Collagenase Therapy. J. of Urology 135: 641-647, March 1986
4. M. K. Gelbard, "Controlled Vacuum . . . Deformity" Urology (Oct. 1990) v. 36, #4. pp. 367-369
5. Gelbard, M.K., James, K., Riach, P., Dorey, F. Collagenase Versus Placebo in the Treatment of Peyronie's Disease: A Double-Blind Study. J. of Urology Vol. 149: 56-58 January 1993
6. F. Bernard, et. al. "Arterial Evaluation . . . " in J. Rajfer Common Problems in Infertility and Impotence, Chicago. Year Book Medical Publishers 1990 p 258-265
The possible side effects of XIAFLEX® can be very serious. Here is a quote directly from the XIAFLEX® website:
"XIAFLEX® can cause serious side effects, including:
Want to pay $30,000 for minimal results and risk that?
We live in a society that seems to demand a drug or "quick fix" for every situation. Whether it is the best solution or not.
In the case of Peyronies "disease", or a bent penis, drugs and injections have proven to be the least effective means of recovery.
And, Penile Surgery has proven pure insanity! The possible side effects include impotence, inability to achieve a hard erection, loss of sensation, urinary problems, pain, a shorter erection... Most men who undergo penile surgery will suffer from at least one of these side effects. It's just crazy!
Only surgery, XIAFLEX®, and penis traction have been clinically proven to straighten a bent penis. And, the traction method has been clinically proven to be the Safest and surest way to fix a bent penis.
The traction method was developed by a penile surgery specialist named Dr. Jorn Ege Siana, MD in 1994.
Correct traction is now medically approved and currently recommended by doctors in 29 countries around the world.
The real beauty of it is: you can get the best medically approved traction devices in the world for about $300. Compare that to the collagenase treatment for $30,000 that are only 35% effective at best, or, surgery that will cost you $8,000 - $19,000 which leaves 65% of men unhappy with the procedure at the 5 year mark.
“....over 65% of patients were unhappy with the outcomes of the Peyronie's surgery at 5-year follow-up. Penile length loss and worsening of erectile dysfunction was the most common reason for dissatisfaction.”
reference: Dr. Nelson Bennett,
“Five-year follow-up of Peyronie's graft surgery: outcomes and patient satisfaction.”
There are currently 23 different kinds of traction units available on the market today. Not all are medically approved. Some devices are definitely dangerous!
I have researched all of them. Only two meet all of my
requirements for safety, reliability, and results. These two units were
both designed by Dr. Siana. They are Pro Extender
and Quick Extender Pro.
Both are medically approved and made of medical grade materials. And both are Guaranteed to work or you get your money back.
To actually straighten a penile bend, the only three methods available are surgery, XIAFLEX® injections, and penis traction.
Penis surgery either shortens the shaft, or adds a graft of tissue to lengthen it. But, the side effects of either surgery can be so horrific and debilitating that surgery seems insane when the tissue can be safely and easily lengthened with simple correct traction.
Collagenase XIAFLEX® Injections for $30,000 have have a 35% effectiveness and their own possible serious side effects.
Correct Penis Traction Therapy is the only straightening method that has been clinically proven to be fully effective in almost every case, Safe, and free of dangerous possible side effects. It is so effective that it is now medically endorsed and recommended in 29 countries.
What makes the most sense to You?
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